Happy Herb Co
St. John's Wort
St. John's Wort
EFFECTS
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Traditionally used as a wound healer due to its antimicrobial, anti-inflammatory, analgesic and astringent properties. It is also helpful internally in cases of neuralgia, sciatica, rheumatic pain, as well as anxiety and tension. More recently, St. John's Wort has become popular as an antidepressant, with research supporting this use. It supports the nervous system, and is thought to optimise the levels of neurotransmitters, particularly serotonin.
Traditionally used as a wound healer due to its antimicrobial, anti-inflammatory, analgesic and astringent properties. It is also helpful internally in cases of neuralgia, sciatica, rheumatic pain, as well as anxiety and tension. More recently, St. John's Wort has become popular as an antidepressant, with research supporting this use. It supports the nervous system, and is thought to optimise the levels of neurotransmitters, particularly serotonin.
St John's Wort Uses & Actions
St John's Wort Uses & Actions
Primary Uses: Neuralgia, Wound Healing, Depression, Anxiety, and Menopause.
Key Herbal Actions: Nervine Tonic, and Vulnerary.
Ingredients
Ingredients
Content: St. John's Wort (Hypericum perforatum) Dried herb
PREPARATION
PREPARATION
Preparation: 1/2 - 1 tsp/cup, steep 10 minutes. Take 3 times daily.
PHYTOTHERAPY
PHYTOTHERAPY
St. Johns Wort
Hypericum perforatum herba (flowering aerial parts) contains phloroglucinols such as hyperforin, together with naphthodianthrones (hypericin, pseudohypericin) and a supporting flavonoid/phenolic matrix.¹,² Experimental work with standardized extracts highlights hyperforin as a key contributor to antidepressant-like activity via non-selective inhibition of neurotransmitter uptake, affecting serotonin, noradrenaline, dopamine, GABA and glutamate transporters in vitro, as well as interacting with certain receptor systems and ion channels.¹
EMA monograph data describe well-characterised dry and liquid extracts prepared from the aerial parts and emphasize that hyperforin-containing preparations can induce cytochrome P450 (notably CYP3A4) and P-glycoprotein, with consequences for the metabolism and transport of co-administered medicines.²
This information is for educational purposes only and does not refer to the effects of any specific product.
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- Mennini, T., & Gobbi, M. (2004). The antidepressant mechanism of Hypericum perforatum. Life Sciences, 75(9), 1021–1027. https://doi.org/10.1016/j.lfs.2004.04.005
2. European Medicines Agency. (2022). European Union herbal monograph on Hypericum perforatum L., herba (Revision 1) (EMA/HMPC/7695/2021). European Medicines Agency. https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-hypericum-perforatum-l-herba-revision-1_en.pdf
Specifications
Specifications
St. John's Wort by Happy Herb Co.
Other Names: Hypericum perforatum
Grown in: Hungary
Organic Status: Australian certified before repackaging
Plant Parts: Aerials
Packaging: Home compostable, reusable zip lock pouch
Vegan Friendly
Precautions
Precautions
- Avoid using St. John’s wort with any pharmaceutical medications as it increases the rate of drug metabolism.
- St. John’s Wort can cause photosensitivity.
- Discontinue use 3 days before surgery.
For specific herb contraindications, see our Herb Hub for more detailed information.
Happy Herb Co provides referenced information for educational purposes only, and does not make any therapeutic claims for any of their products.
Please seek advice from a healthcare provider if you wish to use herbs for therapeutic purposes.

St John's Wort
A restorative effect on the nervous system and nerve tissue, helping to reverse damage and easing the pain of pulled muscles and ligaments, neuralgia, rheumatism and arthritis, fibromyalgia and sciatica.
My daily antidepressant not the same without it. Works wonders!




