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Precautions

Because of the potential toxicity of its active constituent lobeline, Lobelia is not sold for internal use in Australia. In some other countries it is still used internally in very small amounts, usually under the guidance of a herbalist or naturopath. In large amounts Lobelia can cause vomiting.

References

Stead LF1, Hughes JR. "Lobeline for smoking cessation." Cochrane Database Syst Rev. 2012 Feb 15;2:CD000124.

Farook JM1, Lewis B, Gaddis JG, Littleton JM, Barron S. "Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice." Physiol Behav. 2009 Jun 22;97(3-4):503-6.

McChargue DE1, Collins FL Jr, Cohen LM. "Effect of non-nicotinic moist snuff replacement and lobeline on withdrawal symptoms during 48-h smokeless tobacco deprivation." Nicotine Tob Res. 2002 May;4(2):195-200.

Roni MA1, Rahman S. "Antidepressant-like effects of lobeline in mice: behavioral, neurochemical, and neuroendocrine evidence." Prog Neuropsychopharmacol Biol Psychiatry. 2013 Mar 5;41:44-51.